The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors

Abstract It is well established that genetics, environment, and interplay between them play a crucial role in adult disease. We aimed to evaluate the of early life nutrition, interaction them, on optimal health. As part large international consortium (n ~ 154,000), we identified 60 SNPs associated with both birthweight Utilising Raine Study, developed polygenic score (BW-PGS) based examined relationships BW-PGS adulthood cardiovascular risk factors, specifically evaluating interactions nutrition. Healthy nutrition was beneficial for all individuals; longer duration any breastfeeding particularly lower BMI Systolic Blood Pressure those higher BW-PGS. Optimal offers greatest benefit reduce obesity hypertension genetically predisposed high birthweight. This provides an example how precision medicine can improve